The pipecolate location of rapamycin construction seems essential for rapamycin-binding to FKBP12. This move is necessary for even more binding of rapamycin on the mTOR kinase, which can be The true secret enzyme in lots of Organic actions of rapamycin.[46]Belamarine(2016) Trehalose upregulates progranulin expression in human and mouse models of GR